Overview

Instrumental liquid chromatography is an analysis are widely used to determine purity, the impurities, and the degradation products of pharmaceuticals.

The focus of most validation work is on the methodology, the standard operating procedure (SOP). But validation of the instrumentation and other associated items of column, solvents, and other reagents and chemicals is also an area of focus in an audit.

Why should you Attend

In order to meet US EPA or FDA requirements, a method must meet many stringent requirements. The more important of these specific analytical methods are method validation and instrument validation. To not do so is a non-compliance in which any data is not usable or reportable.

Areas Covered in the Session

• Instrument validation
  • The Pumping System
  • The Column
  • The Detection System
  • The Data System
• Method Validation
  • Accuracy
  • Precision and the various measures of precision (repeatability, reproducibility, ruggedness, robustness)
  • Limits of detection and Quantitation, Linearity
  • Selectivity, Interferences, and Specificity
  • Sensitivity
  • Solution Stability

Who Will Benefit

• Chemists and Laboratory Assistants who Perform HPLC or UPLC Analyses Under GLP or ISO 17025

Speaker Profile

John C. Fetzer has had over 30 year experience in HPLC methods development. He has authored or co-authored over 50 peer-reviewed papers onl iquid chromatography, has served on the editorial advisory boards of the Journal of Chromatography, Analytical Chemistry, and Analytical and Bioanalytical Chemistry.